Is ES worse in the winter like SAD?

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Re: Is ES worse in the winter like SAD?

Plop Plop
With reference to " Explaining Unexplained Illnesses" by Martin Pall.   The PONI gene could at least explain in part why EHSs are more effected by EMFs.  Yes its another EI  pollutant risk.  Ignored due to a lack of trials before the mass introduction of poisons into our food.


https://en.wikipedia.org/wiki/PON1

"PON1 is responsible for hydrolysing organophosphate pesticides and nerve gasses. Polymorphisms in the PON1 gene significantly affect the catalytic ability of the enzyme.[10]

PON1 (paraoxonase 1) is also a major anti-atherosclerotic component of high-density lipoprotein (HDL).[11][12] The PON1 gene is activated by PPAR-γ, which increases synthesis and release of paraoxonase 1 enzyme from the liver, reducing atherosclerosis.[13]

The "natural" substrates for PON1 appear to be lactones.[14] However, PON1 has evolved to be a highly promiscuous enzyme capable of hydrolysing a wide variety of substrates such as lactones (including a number of important pharmaceutical agents such as statins), glucuronide drugs, thiolactones, arylesters, cyclic carbonates, organophosphorus pesticides and nerve gases such as sarin, soman and VX, oestrogen esters and lipid-peroxides(oxidised lipids)."

Who knows may be one day they may trial poisons before using them on foods.  Drug trail standards would not have allowed us to be exposed so how did the poisons pesticide industry by pass these controls?  I expect it cost a few bucks but was "worth" it as they have never paid out even when told to by the EU Court as they dumped it on the Government for licensing them and they had "no money".  It all stinks of corruption. And they are still doing it. What a justice system. But then we are "invalids"
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Re: Is ES worse in the winter like SAD?

Plop Plop
Clinical significance

PON1 was first discovered through its ability to hydrolyse and therefore detoxify organophosphorus compounds which are widely used as pesticides and nerve gases. Despite decades of research it is only now becoming clear that PON1 protects humans from the acute and chronic harmful effects of these compounds[20][21] Low PON1 activity found in children may increase their susceptibility to organophosphates. Oxidised-lipids are the major cause of inflammation and are responsible for the initiation and/or propagation of several inflammatory diseases including atherosclerosis (heart disease and stroke), diabetes, liver and kidney diseases, rheumatic diseases, eye diseases (macular degeneration), cancer and HIV infection[citation needed]. Because of its ability to destroy oxidised-lipids PON1 appears to play some role in all these diseases. However, the greatest research interest has been the role of PON1 in atherosclerosis, where, because of its ability to remove harmful oxidised-lipids, PON1 protects against the development of atherosclerosis[22] PON1 also protects against bacterial infection by destroying the bacterial signalling molecules that cause gram negative bacteria to invade human tissue and form colonies, thus PON1 contributes to the bodies innate immunity[23] Recently it has been suggested that PON1 has a role in healthy aging, however, the mechanism is currently unknown[24]

PON1 activity is low in infants compared to adults. A study of Mexican-American children showed that PON1 activity increased 3.5 times between birth and age seven.[25] An association between PON1 gene polymorphism and susceptibility to Parkinson's disease was not found in a Chinese population.[26]

Its a bit "jump and look afterwards"!   Think profit first and cover up by the next Government that cant think more than 4 years ahead!  Cannot any one making these decisions see past their bottom line?
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